IHC PMS2 on a Cervix Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation

PMS2 is a gene that encodes for DNA repair proteins involved in mismatch repair. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells.

Along with MLH1, MSH2 and MSH6, PMS2 is helpful in diagnosing MSI. Tumors with low-level MSI show unfavorable pathological characteristics compared to tumors with none and tumors with high-level MSI.

Antibody Type Mouse Monoclonal Clone BSB-130
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Nuclear Control Breast, Skin, Cervix, Salivary Gland, Tonsil, Ch CA, SCC
Presentation Anti-PMS2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB-2373-3 Tinto Predilute Ready-To-Use 3.0 ml
BSB-2373-7 Tinto Predilute Ready-To-Use 7.0 ml
BSB-2373-15 Tinto Predilute Ready-To-Use 15.0 ml
BSB-2373-01 Concentrate 1:10-1:25 0.1 ml
BSB-2373-05 Concentrate 1:10-1:25 0.5 ml
BSB-2373-1 Concentrate 1:10-1:25 1.0 ml
BSB-2373-CS Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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