IHC of p63 on an FFPE Basal Cell Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation In addition to p53, mammalian cells contain two homologous genes, p63 and p73. These genes give rise to the expression of proteins that are highly similar to p53 in structure and function. In particular, p63 and p73 proteins can induce p53-responsive genes and elicit programmed cell death. p73 and p63 are important during development and differentiation. In particular, p63 appears to be primarily implicated in epithelial development.

Anti-p63 to human p63 protein labels an epitope common to all six p63 isotypes (TAp63α, TAp63β, TAp63γ, ΔNp63α, ΔNp63β, ΔNp63γ). p63 labels the nuclei of myoepithelial cells in the prostate gland as well as breast tissue, making it useful in differentiating benign vs. malignant prostate lesions and breast lesions.

Antibody Type Mouse Monoclonal Clone 4A4
Isotype IgG2a/K Reactivity Paraffin, Frozen
Localization Nuclear Control Prostate, Breast, Skin, Salivary Gland
Presentation p63 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3602 Prediluted Ready-To-Use 3.0 ml
BSB 3603 Prediluted Ready-To-Use 7.0 ml
BSB 3604 Prediluted Ready-To-Use 15.0 ml
BSB 3605 Concentrated 1:50-1:200 0.1 ml
BSB 3606 Concentrated 1:50-1:200 0.5 ml
BSB 3607 Concentrated 1:50-1:200 1.0 ml
BSB 3608 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.