IHC of LMO2 on an FFPE Lymphoblastic Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation LIM domain only 2 (rhombotin-like 1), also known as LIM Domain Only Protein 2 and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene. LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved.

HGAL and LMO2 have been found helpful in classifying difficult cases of Follicular Lymphoma (FL) as an adjunct in the identification of FL of the nongastric GI tract. LMO2 expression has been reported to be special feature of GC DLBCL (Diffuse Large B Cell Lymphoma of germinal center subtype) which can be used as a diagnostic marker.  LMO2 has shown usefulness as part of an IHC panel of germinal center-associated markers in eliminating cases of Diffuse Follicle Center Lymphoma. This is accomplished by taking into consideration the histologic and immunoarchitectural spectrum of Nodal Marginal Zone Lymphoma (NMZL) and the immunohistochemical analysis for CD43, CD23, CD21, BCL6, HGAL, and LMO2 in the diagnosis of NMZL.

Antibody Type Rabbit Monoclonal Clone RBT-LM02
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Tonsil, Spleen, Placenta, Follicular and Lymphoblastic Lymphoma
Presentation LM02 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3574 Prediluted Ready-To-Use 3.0 ml
BSB 3575 Prediluted Ready-To-Use 7.0 ml
BSB 3576 Prediluted Ready-To-Use 15.0 ml
BSB 3577 Concentrated 1:50-1:200 0.1 ml
BSB 3578 Concentrated 1:50-1:200 0.5 ml
BSB 3579 Concentrated 1:50-1:200 1.0 ml
BSB 3580 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.