Lamin-B1 Antibody Immunohistochemistry on an FFPE Colon Adenocarcinoma Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation|
Lamin-B1 is an intermediate filament protein that in humans is encoded by the gene LMNB1. B-type Lamin along with A-type Lamin line the inner surface of the nuclear envelope and form a dynamic structure that is disassembled and reassembled each time a cell enters mitosis. Lamin-B1 plays a central role in chromatin organization, gene positioning, DNA replication and repair, cell cycle progression, stress responses, proliferation and differentiation.
Lamin-B1 loss is associated with cellular senescence and a broad range of aging-related diseases such as cardiovascular diseases and cancers. Recent studies showed Lamin-B1 deficiency promotes Lung Cancer development and metastasis by epigenetic derepression of RET, as well as malignancy and poor prognosis in Gastric Cancer. It has been observed that Lamin-B1 levels are reduced in Lung Cancer patients compared to normal Lung tissue and that lower expression of Lamin-B1 antibodywas associated with higher tumor grade. The levels of lamin A, on the other hand, were not altered in human Lung Tumors, indicating that the different types of lamins have distinct functions in lung carcinogenesis. Overexpression of Lamin-B1 antibody can also indicate poor prognosis in Colon and Pancreatic Cancers.
|Antibody Type||Rabbit Monoclonal||Clone||RBT-LMNB1|
|Localization||Nuclear||Control||Colon, Breast, Fallopian Tube, Tonsil, Testis, Transitional Cell Carcinoma, T Cell Lymphoblastic Lymphoma, Colon Adenocarcinoma|
|Presentation||Lamin-B1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|