il6 il-6 anti-il6 anti-il-6 antibody immunohistochemistry ihc

IL-6 Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue

Specification Sheets
Safety Data Sheet
Spanish (Español)
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Interleukin-6 is a cytokine that regulates inflammation pathways of the classic and trans-signaling cascades, often involved in metabolic, autoimmune and inflammatory conditions such as IgA nephropathy, lupus nephritis, and chronic kidney disease. The ligation of IL-6/IL-6R activates the JAK/STAT3 (cell survival and proliferation) and MAPK (cell growth and protein production) signaling pathways. 

IL-6 participates in autoimmune and inflammatory conditions such as arthritis, where it triggers the differentiation of CD4+ T cells into Th17 helper cells, suppresses differentiation into T regulatory cells, and prevents T helper apoptosis along with IL-2. IL-6 also induces differentiation of monocytes into macrophages and uses follicular T helper cells to induce B cell activation, upregulating IgG production. IL-6 antibody reactivity is often found in immune tissues, podocytes, mesangial cells, endothelial and epithelial cells. Il-6 is important in cancer cell growth and suppression of the immune system in the tumor microenvironment, metastasis and renewal of cancer stem cells.

Antibody TypeMouse MonoclonalCloneBSB-140
IsotypeIgG2bReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranaousControlTestis, Lung, Stomach, Kidney, Transitional Cell Carcinoma
PresentationIL-6 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB-3707-3PredilutedReady-To-Use3.0 ml
BSB-3707-7PredilutedReady-To-Use7.0 ml
BSB-3707-15PredilutedReady-To-Use15.0 ml
BSB-3707-01Concentrated1:50-1:2000.1 ml
BSB-3707-05Concentrated1:50-1:2000.5 ml
BSB-3707-1Concentrated1:50-1:2001.0 ml
BSB-3707-CSControl Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: il-6, il6, anti-il6, anti-il-6, il6 antibody, anti-il-6 antibody, cytokine storm, cytokine storm syndrome, cytokine storm antibody, cytokine storm antibodies, sars-cov-2 receptors, sars cov-2 receptors, covid-19 receptors, sars-cov-2 antibodies sars-cov-2 ihc, sars-cov-2 immunohistochemistry, IL 6, IL6, interleukin 6, sc57315, sc-57315, 57315, anti-IL-6, anti IL-6, anti-Il6, anti Il6, anti-IL 6, anti IL 6, anti-Interleukin 6, anti Interleukin 6, Ifnb2, ILg6, Interleukin 6 interferon beta 2