IL-6 Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation|
Interleukin-6 is a cytokine that regulates inflammation pathways of the classic and trans-signaling cascades, often involved in metabolic, autoimmune and inflammatory conditions such as IgA nephropathy, lupus nephritis, and chronic kidney disease. The ligation of IL-6/IL-6R activates the JAK/STAT3 (cell survival and proliferation) and MAPK (cell growth and protein production) signaling pathways.
IL-6 participates in autoimmune and inflammatory conditions such as arthritis, where it triggers the differentiation of CD4+ T cells into Th17 helper cells, suppresses differentiation into T regulatory cells, and prevents T helper apoptosis along with IL-2. IL-6 also induces differentiation of monocytes into macrophages and uses follicular T helper cells to induce B cell activation, upregulating IgG production. IL-6 antibody reactivity is often found in immune tissues, podocytes, mesangial cells, endothelial and epithelial cells. Il-6 is important in cancer cell growth and suppression of the immune system in the tumor microenvironment, metastasis and renewal of cancer stem cells.
|Antibody Type||Mouse Monoclonal||Clone||BSB-140|
|Localization||Cytoplasmic, Membranaous||Control||Testis, Lung, Stomach, Kidney, Transitional Cell Carcinoma|
|Presentation||IL-6 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|