il6 il-6 anti-il6 anti-il-6 antibody immunohistochemistry ihc

IL-6 Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue

Specification Sheets
Safety Data Sheet

SDS

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Intended Use For In Vitro Diagnostic Use
Summary and Explanation

Interleukin-6 is a cytokine that regulates inflammation pathways of the classic and trans-signaling cascades, often involved in metabolic, autoimmune and inflammatory conditions such as IgA nephropathy, lupus nephritis, and chronic kidney disease. The ligation of IL-6/IL-6R activates the JAK/STAT3 (cell survival and proliferation) and MAPK (cell growth and protein production) signaling pathways. 

IL-6 participates in autoimmune and inflammatory conditions such as arthritis, where it triggers the differentiation of CD4+ T cells into Th17 helper cells, suppresses differentiation into T regulatory cells, and prevents T helper apoptosis along with IL-2. IL-6 also induces differentiation of monocytes into macrophages and uses follicular T helper cells to induce B cell activation, upregulating IgG production. IL-6 antibody reactivity is often found in immune tissues, podocytes, mesangial cells, endothelial and epithelial cells. Il-6 is important in cancer cell growth and suppression of the immune system in the tumor microenvironment, metastasis and renewal of cancer stem cells.

Antibody Type Mouse Monoclonal Clone BSB-140
Isotype IgG2b Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranaous Control Testis, Lung, Stomach, Kidney, Transitional Cell Carcinoma
Presentation IL-6 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB-3707-3 Prediluted Ready-To-Use 3.0 ml
BSB-3707-7 Prediluted Ready-To-Use 7.0 ml
BSB-3707-15 Prediluted Ready-To-Use 15.0 ml
BSB-3707-01 Concentrated 1:50-1:200 0.1 ml
BSB-3707-05 Concentrated 1:50-1:200 0.5 ml
BSB-3707-1 Concentrated 1:50-1:200 1.0 ml
BSB-3707-CS Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: il-6, il6, anti-il6, anti-il-6, il6 antibody, anti-il-6 antibody, cytokine storm, cytokine storm syndrome, cytokine storm antibody, cytokine storm antibodies, sars-cov-2 receptors, sars cov-2 receptors, covid-19 receptors, sars-cov-2 antibodies sars-cov-2 ihc, sars-cov-2 immunohistochemistry