il1b il-1b anti-il1b anti-il-1b antibody immunohistochemistry ihc

IL-1b Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

IL-1b has multiple functions as a major pro-inflammatory cytokine regulated by NFKB. The 31 kDa precursor is biologically inactive in the cytosol, and is processed to its active 17 kDa mature form by Caspase 1 in special lysosomes. The beta-barrel cytokine is secreted to participate in pathways of angiogenesis, antigen presentation, adhesion molecule expression, inflammatory cell activity, and expression of matrix degrading enzymes. 

IL-1b antibody expression is found in tumor-infiltrating myeloid cells, which then produce VEGF and other angiogenesis-related factors, promoting growth in multiple tumor types. IL-1b has a role in tumor metastasis and helps maintain an inflammatory tumor environment, but has also demonstrated an anti-tumorigenic function in recruiting immune cells and driving activation of the Th1 response against B cell myeloma and lymphoma. Pathogen-Associated Molecular Patterns can also initiate expression of IL-1b antibody, helping to accumulate neutrophils and promote inflammation and fibrosis at the infection site.

Antibody Type Mouse Monoclonal Clone BSB-139
Isotype IgG2b Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Colon, Pancreas, Liver, Stomach, Brain, Testis, Lung, Transitional Cell Carcinoma, Tonsil
Presentation IL-1b antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB-3706-3 Prediluted Ready-To-Use 3.0 ml
BSB-3706-7 Prediluted Ready-To-Use 7.0 ml
BSB-3706-15 Prediluted Ready-To-Use 15.0 ml
BSB-3706-01 Concentrated 1:50-1:200 0.1 ml
BSB-3706-05 Concentrated 1:50-1:200 0.5 ml
BSB-3706-1 Concentrated 1:50-1:200 1.0 ml
BSB-3706-CS Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: il-1b, il1b, anti-il1b, anti-il-1b, il1b antibody, anti-il-1b antibody, cytokine storm, cytokine storm syndrome, cytokine storm antibody, cytokine storm antibodies, sars-cov-2 receptors, sars cov-2 receptors, covid-19 receptors, sars-cov-2 antibodies sars-cov-2 ihc, sars-cov-2 immunohistochemistry
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