il-1a anti-il-1a il1a anti-il1a antibody immunohistochemistry ihc

IL-1a Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

IL-1a is a dual-function cytokine, acting as a transcription factor and a cell-signaling molecule. The 31 kDa precursor form is biologically active in the cytosol and as a membrane protein. IL-1a can be cleaved by calpain into the biologically active 17 kDa mature form that regulates the expression of NFKB, and IFN-y and its effectors. Cancer stem cells use IL-1a to maintain an inflammatory tumor microenvironment, however IL-1a is also used in recruiting and proliferating immune cells as a necrosis alarmin in damaged epithelia. IL-1a induces NFKB and STAT3 signaling that supports cancer stem cell growth. IL-1a is a major cytokine in innate inflammation signaling pathways, and is thus involved in many inflammatory diseases and reactions to oxidative stress. 

IL-1a antibody is involved in cancer cell cross-talk and metastasis, and the secretion of cell growth, angiogenesis, and inflammation factors as a Damage-Associated Molecular Pattern. Higher expression of IL-1a has been found in gastric cancer and squamous carcinomas of the head and neck that exhibit distant metastasis. IL-1a has also been associated with tumor de-differentiation and metastasis in breast cancer, and with tumor proliferation and angiogenesis in pancreatic cancer.

Antibody Type Mouse Monoclonal Clone BSB-138
Isotype IgG2b Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Kidney, Colon, Adrenal gland, Testis, Lung
Presentation IL-1a is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB-3705-3 Prediluted Ready-To-Use 3.0 ml
BSB-3705-7 Prediluted Ready-To-Use 7.0 ml
BSB-3705-15 Prediluted Ready-To-Use 15.0 ml
BSB-3705-01 Concentrated 1:50-1:200 0.1 ml
BSB-3705-05 Concentrated 1:50-1:200 0.5 ml
BSB-3705-1 Concentrated 1:50-1:200 1.0 ml
BSB-3705-CS Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: il-1a, il1a, anti-il1a, anti-il-1a, il1a antibody, anti-il-1a antibody, cytokine storm, cytokine storm syndrome, cytokine storm antibody, cytokine storm antibodies, sars-cov-2 receptors, sars cov-2 receptors, covid-19 receptors, sars-cov-2 antibodies sars-cov-2 ihc, sars-cov-2 immunohistochemistry
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