il-1a anti-il-1a il1a anti-il1a antibody immunohistochemistry ihc

IL-1a Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue

Specification Sheets
Safety Data Sheet
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Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

IL-1a is a dual-function cytokine, acting as a transcription factor and a cell-signaling molecule. The 31 kDa precursor form is biologically active in the cytosol and as a membrane protein. IL-1a can be cleaved by calpain into the biologically active 17 kDa mature form that regulates the expression of NFKB, and IFN-y and its effectors. Cancer stem cells use IL-1a to maintain an inflammatory tumor microenvironment, however IL-1a is also used in recruiting and proliferating immune cells as a necrosis alarmin in damaged epithelia. IL-1a induces NFKB and STAT3 signaling that supports cancer stem cell growth. IL-1a is a major cytokine in innate inflammation signaling pathways, and is thus involved in many inflammatory diseases and reactions to oxidative stress. 

IL-1a antibody is involved in cancer cell cross-talk and metastasis, and the secretion of cell growth, angiogenesis, and inflammation factors as a Damage-Associated Molecular Pattern. Higher expression of IL-1a has been found in gastric cancer and squamous carcinomas of the head and neck that exhibit distant metastasis. IL-1a has also been associated with tumor de-differentiation and metastasis in breast cancer, and with tumor proliferation and angiogenesis in pancreatic cancer.

Antibody TypeMouse MonoclonalCloneBSB-138
IsotypeIgG2bReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlKidney, Colon, Adrenal gland, Testis, Lung
PresentationIL-1a is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB-3705-3PredilutedReady-To-Use3.0 ml
BSB-3705-7PredilutedReady-To-Use7.0 ml
BSB-3705-15PredilutedReady-To-Use15.0 ml
BSB-3705-01Concentrated1:50-1:2000.1 ml
BSB-3705-05Concentrated1:50-1:2000.5 ml
BSB-3705-1Concentrated1:50-1:2001.0 ml
BSB-3705-CSControl Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: il-1a, il1a, anti-il1a, anti-il-1a, il1a antibody, anti-il-1a antibody, cytokine storm, cytokine storm syndrome, cytokine storm antibody, cytokine storm antibodies, sars-cov-2 receptors, sars cov-2 receptors, covid-19 receptors, sars-cov-2 antibodies sars-cov-2 ihc, sars-cov-2 immunohistochemistry, IL1A, IL-1α, IL-1alpha, IL-1 alpha, IL-1a, IL-1 a, IL 1α, IL1α, anti-IL-1α, anti IL-1α, anti-IL1A, anti IL1A, anti-IL 1α, anti-IL1α, anti IL 1α, anti IL1α, IL-1F1, Hematopoietin-1, Interleukin-1 alpha, anti-IL-1 alpha, anti IL-1 alpha, anti-IL-1F1, anti IL-1F1, anti-Hematopoietin-1, anti Hematopoietin-1, anti-Interleukin-1 alpha, anti Interleukin-1 alpha, hematopoietin 1, IL 1 alpha, IL 1A, IL1, IL1 ALPHA, IL1F1, interleukin 1 alpha, preinterleukin 1 alpha, pro interleukin 1 alpha