IFN-y Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation|
IFN-γ is a dimerized soluble cytokine and the only member of the type II interferon. In humans, IFN-γ is encoded by the IFNG gene and is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. IFN-γ is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocytes effector T cells once antigen-specific immunity develops as part of the adaptive immune response. IFN-γ is also produced by non-cytotoxic innate lymphoid cells.
IFN-γ interacts with its receptors interferon gamma receptor 1 and interferon gamma receptor 2 and activates them. IFN-γ binding to the receptors activates the JAK-STAT pathway. IFN-γ also binds to the glycosaminoglycan heparan sulfate and inhibits its biological activity. IFN-γ is used to treat Chronic Granulomatous Disease and Osteopetrosis, also has potential as cancer immunotherapy to improve survival in Bladder Carcinoma, Melanoma, and Ovarian Carcinoma.
|Antibody Type||Mouse Monoclonal||Clone||BSB-161|
|Localization||Cytoplasmic, Membranous||Control||Stomach, Fallopian Tube, Colon, Lung Adenocarcinoma, Ductal Breast Carcinoma, Pancreatic Adenocarcinoma|
|Presentation||Anti-IFN-y is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|