inf-y. infy, anti-inf-y anti-infy

IFN-y Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue Tissue

Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

IFN-γ is a dimerized soluble cytokine and the only member of the type II interferon. In humans, IFN-γ is encoded by the IFNG gene and is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. IFN-γ is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocytes effector T cells once antigen-specific immunity develops as part of the adaptive immune response. IFN-γ is also produced by non-cytotoxic innate lymphoid cells.

IFN-γ interacts with its receptors interferon gamma receptor 1 and interferon gamma receptor 2 and activates them. IFN-γ binding to the receptors activates the JAK-STAT pathway. IFN-γ also binds to the glycosaminoglycan heparan sulfate and inhibits its biological activity. IFN-γ is used to treat Chronic Granulomatous Disease and Osteopetrosis, also has potential as cancer immunotherapy to improve survival in Bladder Carcinoma, Melanoma, and Ovarian Carcinoma.

Antibody TypeMouse MonoclonalCloneBSB-161
IsotypeIgG2aReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlStomach, Fallopian Tube, Colon, Lung Adenocarcinoma, Ductal Breast Carcinoma, Pancreatic Adenocarcinoma
PresentationAnti-IFN-y is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB-3734-3PredilutedReady-To-Use3.0 ml
BSB-3734-7PredilutedReady-To-Use7.0 ml
BSB-3734-15PredilutedReady-To-Use15.0 ml
BSB-3734-01Concentrated1:50-1:2000.1 ml
BSB-3734-05Concentrated1:50-1:2000.5 ml
BSB-3734-1Concentrated1:50-1:2001.0 ml
BSB-3734-CSControl Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: IGN-y, IFNy, IFN y, anti-ifn-y, anti-ifny, anti-ifn y, gamma, ifn-gamma, ifn gamma, anti-ifn-gamma