ifn-a, anti-ifn-a, ifna, anti-ifna, ifn a, anti-ifn a, IFN-α, anti-IFN-α

IFN-a Antibody Immunohistochemistry on an FFPE Papillary Thyroid Carcinoma Tissue

Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Type I interferons are a large subgroup of interferon proteins that help regulate the immune system by binding to IFN-⍺ receptors. IFN-⍺ (IFN-a) is produced mainly by plasmacytoid dendritic cells and involved in innate immunity against viral infections. Binding of IFN-⍺ to its receptor leads to downstream signalling and expression of numerous different IFN-stimulated genes. These genes encode antiviral proteins that directly inhibit viral replication as well as modulate immune function.

Studies have shown IFN-a strongly modulates innate and adaptive immune responses in the host by enhancing the proliferation, cytotoxicity and IFN-γ secretion of NK cells, as well as acting as a pyrogenic factor by altering the activity of thermosensitive neurons in the hypothalamus which causes fever. It does this by binding to opioid receptors and eliciting the release of prostaglandin-E2. IFN-a can also interact with the μ-opioid receptor to act as an analgesic. Additionally, recent studies have shown that Type 1 IFNs stimulate secretion of IP-10 (CXCL10) which is a critical chemokine to recruit effector T cells to the tumor microenvironment and IP-10 knockout mice exhibit a phenotype with compromised effector T cell generation and trafficking. Type 1 IFNs also induce MHC class 1 upregulation on tumor cells which can enhance antitumor CD8 T cell effector response in the tumor microenvironment.

Antibody TypeMouse MonoclonalCloneBSB-158
IsotypeIgG2bReactivityParaffin, Frozen
LocalizationCytoplasmic, NuclearControlPlacenta, Fallopian Tube, Stomach, Prostate, Testis, Transitional Cell Carcinoma, Papillary Thyroid Carcinoma
PresentationIFN-a is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB-3733-3PredilutedReady-To-Use3.0 ml
BSB-3733-7PredilutedReady-To-Use7.0 ml
BSB-3733-15PredilutedReady-To-Use15.0 ml
BSB-3733-01Concentrated1:25-1:1000.1 ml
BSB-3733-05Concentrated1:25-1:1000.5 ml
BSB-3733-1Concentrated1:25-1:1001.0 ml
BSB-3733-CSControl Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: ifn-a, anti-ifn-a, ifna, anti-ifna, ifn a, anti-ifn a, IFN-α, anti-IFN-α, inf alpha, ifn-alpha, anti-ifn-alpha