gata-3 antibody, gata3, gata-3, gata 3, anti gata3, anti gata-3, anti gata 3, anti-gata3, anti-gata-3, anti-gata 3, GATA binding protein 3, anti-GATA binding protein 3, anti GATA binding protein 3, GATA binding factor 3, trans acting T cell specific transcription factor GATA 3, mouse monoclonal for immunohistochemistry IHC

GATA3 Antibody Immunohistochemistry on a FFPE Breast Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

GATA3 is a rabbit monoclonal antibody for immunohistochemistry from Bio SB. Trans-acting T-cell-specific transcription factor, GATA-3 is, a protein that in humans is encoded by the GATA3 gene. GATA-3 b regulates luminal epithelial cell differentiation in the mammary gland, is an important regulator of T cell development and plays an important role in endothelial cell biology.

GATA3 is one of the three genes mutated in >10% of breast cancers. Nuclear expression of GATA-3 in breast cancer is considered a marker of luminal cancer in ER+ cancer and luminal androgen responsive cancer in ER-/AR+ tumors. It is highly coexpressed with FOXA1 and serves as negative predictor of basal subtype and HER-2 and is also considered a strong predictor of taxane and platin salts insensitivity.

GATA3 expression is found in urothelial carcinoma, especially in invasive and high grade tumors. Therefore, GATA3 can be used in a panel of antibodies for diagnosis of unknown primary carcinoma, when carcinomas of the breast or bladder are a possibility. Studies have also shown the utility of GATA3 in differntiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine, cervix, anus and lung.

Antibody TypeRabbit MonoclonalCloneEP368
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlBreast, Skin, Cervix, Breast Carcinoma
PresentationGATA3 is a rabbit monoclonal antibody for immunohistochemistry derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 3328PredilutedReady-To-Use3.0 ml
BSB 3329PredilutedReady-To-Use7.0 ml
BSB 3330PredilutedReady-To-Use15.0 ml
BSB 3331Concentrated1:50-1:2000.1 ml
BSB 3332Concentrated1:50-1:2000.5 ml
BSB 3333Concentrated1:50-1:2001.0 ml
BSB 3334Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: gata3, gata-3, gata 3, anti gata3, anti gata-3, anti gata 3, anti-gata3, anti-gata-3, anti-gata 3, GATA binding protein 3, anti-GATA binding protein 3, anti GATA binding protein 3, GATA binding factor 3, trans acting T cell specific transcription factor GATA 3