gab1, anti-gab1, grb2, anti-grb2, hrb2-associated-binding protein 1

GAB1 Antibody Immunohistochemistry on an FFPE Testis Tissue

Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

GRB2-associated-binding protein 1 (GAB1) is encoded by the GAB1 gene. GAB1 is a member of the IRS1-like multisubstrate docking protein family that transduces signals from various tyrosine kinases, such as Met, FGFR1, and EGFR. GAB1 plays a central role in cellular growth response, transformation, and apoptosis, as well as inflammatory responses. GAB1 is involved in the amplification of IL-6- induced MAPK pathway and promotes inflammation.

Somatic mutations of the GAB1 gene have been detected in Breast and Colorectal Cancers and studies have shown that elevated expressions of GAB1 antibody have been associated with Breast Cancer metastasis by dissociating the polarity-associated partitioning defective (PAR) complex and promoting epithelial-to-mesenchymal transition. Upregulation of GAB1 is an indication of unfavorable prognosis for Hepatocellular Carcinoma and Epithelial Ovarian Cancer. GAB1 overexpression has also been seen in Adult Acute Lymphoblastic Leukemia and Medulloblastomas. GAB1 antibody can be used with a panel of immunohistochemical markers in the classification of Medulloblastomas into SHH (sonic hedgehog), WNT (wingless-type murine mammary tumor), or non-SHH/WNT subgroups.

Antibody TypeMouse MonoclonalCloneBSB-155
IsotypeIgG2aReactivityParaffin, Frozen
LocalizationCytoplasmic, Membranous, NuclearControlBreast, Prostate, Testis, Tonsil, Stomach, Transitional Cell Carcinoma
PresentationGAB1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB-3727-3PredilutedReady-To-Use3.0 ml
BSB-3727-7PredilutedReady-To-Use7.0 ml
BSB-3727-15PredilutedReady-To-Use15.0 ml
BSB-3727-01Concentrated1:25-1:1000.1 ml
BSB-3727-05Concentrated1:25-1:1000.5 ml
BSB-3727-1Concentrated1:25-1:1001.0 ml
BSB-3727-CSControl Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: gab1, anti-gab1, grb2, anti-grb2, hrb2-associated-binding protein 1, GRB2 associated binding protein 1, anti-Gab 1, anti Gab 1, anti-GRB2 Associated Binding Protein 1, anti GRB2 Associated Binding Protein 1, Growth Factor Receptor Bound Protein 2-Associated Protein 1, GRB2-Associated-Binding Protein 1, Deafness Autosomal Recessive 26, GRB2-Associated Binder 1, anti GAB1, anti-Growth Factor Receptor Bound Protein 2-Associated Protein 1, anti Growth Factor Receptor Bound Protein 2-Associated Protein 1, anti-GRB2-Associated-Binding Protein 1, anti GRB2-Associated-Binding Protein 1, anti-Deafness Autosomal Recessive 26, anti Deafness Autosomal Recessive 26, anti-GRB2-Associated Binder 1, anti GRB2-Associated Binder 1, GRB2 associated binder 1, Growth factor receptor bound protein 2 associated protein 1