{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"DNA excision repair protein ERCC1 is encoded by the ERCC1 gene on chromosome 19. Excision Repair Cross Complementing 1 (ERCC1) is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair."}]},{"type":"paragraph","children":[{"type":"text","value":"ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer. \n Increased levels of ERCC1 expression may correlate with a lower response to platinum-based chemotherapies. Studies have also showed however, that In non-small cell lung carcinoma (NSCLC), surgically removed tumors that receive no further therapy have a better survival if ERCC1-positive than if ERCC1-negative."}]}]}