IHC of Cytokeratin, MNF116 on an Frozen Basal Cell Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

Cytokeratin MNF116 is a broad-spectrum anti-cytokeratin reacting with intermediate and low-molecular-weight keratins, ranging from 40 through 58 kD, corresponding to cytokeratin 5, 6, 8, 17 and 19. It shows a broad pattern of reactivity with human epithelial tissues from simple glandular epithelial to stratified squamous epithelia, like epidermis, mammary gland ducts, and tracheal epithelium.

Cytokeratin MNF116 is a useful aid for the classification of neoplasms of epithelial origin including Squamous Cell Carcinoma, Small Cell Carcinoma, Sarcomatoid Carcinoma, Spindle Cell Carcinoma, Epithelioid and Spindle Cell component of Malignant Mesothelioma and Adenocarcinoma. A wide range of soft tissue tumors are also positive with cytokeratin MNF116: monophasic and biphasic Synovial Sarcoma, vascular neoplasms including Epithelioid Hemangioendothelioma, Epithelioid Angiosarcoma, Epithelioid Sarcoma. Desmoplastic Small Round Cell Tumors require cytokeratin positivity for diagnosis. Smooth muscle tumors and Plasmacytoma may demonstrate aberrant expression of cytokeratin MNF116.

Antibody Type Mouse Monoclonal Clone MNF116
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Breast, Cervix, Skin, Colon, Colorectal. Gastric, Breast and Prostatic Carcinomas
Presentation Cytokeratin, MNF116, is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3532 Prediluted Ready-To-Use 3.0 ml
BSB 3533 Prediluted Ready-To-Use 7.0 ml
BSB 3534 Prediluted Ready-To-Use 15.0 ml
BSB 3535 Concentrated 1:25-1:100 0.1 ml
BSB 3536 Concentrated 1:25-1:100 0.5 ml
BSB 3537 Concentrated 1:25-1:100 1.0 ml
BSB 3538 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.