cox-2 cox2 anti-cox-2 anti-cox2 anti antibody immunohistochemistry ihc

COX-2 Antibody Immunohistochemistry on an FFPE Adenocarcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, Cyclooxygenase (COX) is an enzyme that is responsible for formation of important biological mediators called prostanoids (including prostaglandins, prostacyclin and thromboxane). Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain; this is the method of action of well-known drugs such as aspirin and ibuprofen. COX-2 inhibition by nonsteroidal anti-inflammatory agents has been shown to decrease angiogenesis and tumor growth and promote apoptosis.

COX-2 antibody overexpression has been associated with increased microvascular density, and VEGF protein expression in head and neck Squamous-cell Carcinomas and is a poor prognostic indicator in this entity as well. COX-2 overexpression has also been suggested as a poor prognostic indicator in Carcinomas of the colon, breast, pancreas, and Adenocarcinomas of the lung.

Antibody TypeRabbit MonoclonalCloneRBT-COX2
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlColon, Testis, Kidney, Placenta, Liver, Fallopian Tube, Pancreas, Tonsil, Thymus, Breast, Adenocarcinoma of Colon, Bladder TCC
PresentationCOX-2 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5358PredilutedReady-To-Use3.0 ml
BSB 5359PredilutedReady-To-Use7.0 ml
BSB 5360PredilutedReady-To-Use15.0 ml
BSB 5361Concentrated1:25-1:1000.1 ml
BSB 5362Concentrated1:25-1:1000.5 ml
BSB 5363Concentrated1:25-1:1001.0 ml
BSB 5364Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: Cox 2, Cox2, PTGS2, sc19999, sc-19999, 19999, anti-Cox-2, anti Cox-2, anti-Cox 2, anti-Cox2, anti Cox 2, anti Cox2, anti cyclooxygenase-2, anti PTGS2, anti-cyclooxygenase-2, anti-PTGS2, cyclooxygenase-2, cyclooxygenase 2b, Cyclooxygenase 2, GRIPGHS, hCox 2, PGG HS, PGH synthase 2, PGHS 2, PHS II, PHS 2, Prostaglandin G H synthase 2, Prostaglandin H2 synthase 2, Prostaglandin endoperoxide synthase 2, prostaglandin endoperoxide synthase 2 prostaglandin G H synthase and cyclooxygenase, cyclooxygenase