cox-2 cox2 anti-cox-2 anti-cox2 anti antibody immunohistochemistry ihc

COX-2 Antibody Immunohistochemistry on an FFPE Adenocarcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, Cyclooxygenase (COX) is an enzyme that is responsible for formation of important biological mediators called prostanoids (including prostaglandins, prostacyclin and thromboxane). Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain; this is the method of action of well-known drugs such as aspirin and ibuprofen. COX-2 inhibition by nonsteroidal anti-inflammatory agents has been shown to decrease angiogenesis and
tumor growth andpromote apoptosis.COX-2 antibody overexpression has been associated with increased microvascular density, and VEGF protein expression in head and neck Squamous-cell Carcinomas and is a poor prognostic indicator in this entity as well. COX-2 overexpression has also been suggested as a poor prognostic indicator in Carcinomas of the colon, breast, pancreas, and Adenocarcinomas of the lung.
Antibody Type Rabbit Monoclonal Clone RBT-COX2
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Colon, Testis, Kidney, Placenta, Liver, Fallopian Tube, Pancreas, Tonsil, Thymus, Breast, Adenocarcinoma of Colon, Bladder TCC
Presentation COX-2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5358 Prediluted Ready-To-Use 3.0 ml
BSB 5359 Prediluted Ready-To-Use 7.0 ml
BSB 5360 Prediluted Ready-To-Use 15.0 ml
BSB 5361 Concentrated 1:25-1:100 0.1 ml
BSB 5362 Concentrated 1:25-1:100 0.5 ml
BSB 5363 Concentrated 1:25-1:100 1.0 ml
BSB 5364 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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