CD57 Antibody Immunohistochemistry on an FFPE Tonsil Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation|
CD57 (NK-1) recognizes an oligosaccharide (MW 100-110 kDa) antigenic determinant on myeloid cells and on a variety of polypeptides, lipids and chondroitan sulfate proteoglycans. This surface antigen is associated with myelin-associated glycoprotein (MAG). The CD57 antigen is present on 15-20% of normal peripheral blood mononuclear cells. It is expressed on a subset of natural killer cells (60%) and on a subset of T-lymphocytes. This carbohydrate is also present on N-CAM in the nervous system.
Follicular Center-cell Lymphomas often contain many NK cells within the neoplastic follicles. CD57 antibody (NK-1) reportedly also reacts with a variety of cell types in non-lymphoid tissues. CD57 antibody stains neuroendocrine cells and their tumors, including Carcinoid Tumor and Medulloblastomas. CD57 also reacts with a variety of cell types in non-lymphoid tissues, including Neurofibroma, Ganglioneuroma, and Prostate Carcinoma.
|Antibody Type||Mouse Monoclonal||Clone||BSB-10 (CD57/B8)|
|Localization||Membranous||Control||Tonsil, Lymph Node|
|Presentation||CD57 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|