CD56 Antibody Immunohistochemistry on an FFPE Neuroblastoma Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation|
CD56 or Neural-Cell Adhesion Molecule (NCAM) is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. CD56 has been implicated in cell-cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory.
Normal cells that stain positively for CD56 antibody include NK cells, activated T-cells, brain and cerebellum, and neuroendocrine tissues. Tumors that are CD56 positive are Myeloma, Myeloid Leukemia, Neuroendocrine tumors, Wilm’s Tumor, Adult Neuroblastoma, NK/T cell Lymphomas, Pancreatic Acinar-cell Carcinoma, Pheochromocytoma, and Small-cell Lung Carcinoma. It is also expressed on some mesodermally-derived tumors (Rhabdomyosarcoma). Ewing’s Sarcoma/PNET is CD56 negative.
|Antibody Type||Mouse Monoclonal||Clone||123C3.D5|
|Localization||Membranous||Control||Pancreas, Tonsil, Neuroblastoma, Brain, Thyroid, Prostate, Colon, Lung SCC|
|Presentation||CD56 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|