CD45RA Antibody Immunohistochemistry on an FFPE Tonsil Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation|
CD45 is a complex molecule and is comprised of different glycoproteins ranging from 180-240 kDa. Expression of CD45 is found on all hemopoietic cells. Detection of the different isoforms can distinguish between different cell forms (e.g., naive T-cells and memory T-cells). CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
CD45RA antibody reacts with mature, non-activated T and B-cells. CD45RA is also reactive with medullary thymocytes, mantle-zone lymphocytes in follicles of lymph nodes, spleen and lymphocytes of the paracortex. CD45RA antibody shows no reactivity with cortical thymocytes, immature T-cells or activated B-cells in germinal centers.
|Antibody Type||Mouse Monoclonal||Clone||4KB5|
|Localization||Membranous||Control||Tonsil, Lymph Node|
|Presentation||CD45RA is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|