cd147 anti-cd147 antibody immunohistochemistry ihc

CD147 Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

CD147 is a transmembrane glycoprotein also known as Basigin or EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), participating in tumor development and viral entry pathways. CD147 is a member of the immunoglobulin superfamily, upregulated in asthmatic, diabetic, and other inflammatory pathways where it induces expression of Matrix Metalloproteinase 1 and 9. CD147 and its effectors are induced by high-glucose concentration in monocytes and promote their migration. CD147 also participates in fibroblast differentiation through TGF-b1-induced signaling pathways, and is a marker of undifferentiated human embryonic stem cells.

CD147 antibody has been found to be upregulated in cancer stem cells, resulting in increased metabolism through lactic acid export, increased production of hyaluronan, inhibiting apoptosis, and acting as a main upstream stimulator of matrix metalloproteinases. In clinical studies, CD147 has been associated with larger tumors, deeper invasion, and more lymphocytes. CD147 also facilitates the entry of malaria parasite Plasmodium falciparum into red blood cells, and the entry of coronaviruses into human cells by binding the spike glycoprotein, functioning as the second receptor for SARS-CoV-2 and potential participant in pulmonary fibrosis. 

Antibody Type Mouse Monoclonal Clone BSB-137
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Membranous, Cytoplasmic Control Testis, Colon, Kidney, Stomach, Brain
Presentation CD147 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB-3704-3 Prediluted Ready-To-Use 3.0 ml
BSB-3704-7 Prediluted Ready-To-Use 7.0 ml
BSB-3704-15 Prediluted Ready-To-Use 15.0 ml
BSB-3704-01 Concentrated 1:50-1:200 0.1 ml
BSB-3704-05 Concentrated 1:50-1:200 0.5 ml
BSB-3704-1 Concentrated 1:50-1:200 1.0 ml
BSB-3704-CS Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: cd147, cd-147 cd 147, anti-cd147, anti-cd-147, cd147 antibody, anti-cd147 antibody, sars-cov-2 receptors, sars cov-2 receptors, covid-19 receptors, sars-cov-2 antibodies sars-cov-2 ihc, sars-cov-2 immunohistochemistry
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