IHC of C3c on a FFPE Lupus Erythmatosus Tissue
IF of C3c on a Frozen Lupus Nephritis Tissue
|Intended Use||For In Vitro Diagnostic Use.
This antibody is intended for use in Immunohistochemical (IHC) and Immunofluorescence (IF) applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.
|Summary and Explanation||Complement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity.
C3 glomerulopathy was recently coined to describe renal biopsy appearances characterized by the presence of glomerular deposits composed predominantly of C3 in the absence of significant amounts of Ig. The presence of C3 in the absence of Ig suggests activation of complement by antibody-independent pathways, typically the alternative pathway, and many patients with this type of renal lesion have evidence of genetic or acquired alternative pathway dysregulation. C3 glomerulopathy has been further divided into dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) based on electron microscopy (EM) appearances. The underlying genetic defect has been identified in some hereditary forms of C3GN such as CFHR5 nephropathy. Lupus nephritis is an inflammation of the kidneys caused by Systemic Lupus Erythematosus. Immunofluorescence reveals positively for IgG, IgA, IgM, C3, and C1q.
|Antibody Type||Rabbit Polyclonal||Clone||Polyclonal|
|Localization||Cytoplasmic, Membranous||Control||Placenta, Kidney, Fallopian Tube, Lupus Erythematosus|
|Presentation||C3c is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|
*Ready-to-Use, for IHC only!