bcl6 bcl-6 bcl 6 anti-bcl6 anti-bcl-6 anti-bcl 6 antibody immunoohistochemistry ihc

bcl-6 Antibody Immunohistochemistry on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

bcl-6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein. Antibodies to this protein stain the germinal center cells in lymphoid follicles, follicular cells and interfollicular cells in Follicular Lymphoma, Diffuse Large B-Cell Lymphomas, Burkitt’s Lymphoma, and the majority of the Reed-Sternberg cells in Nodular Lymphocyte-Predominant Hodgkin’s Disease.

The bcl-6 antibody is also useful in identifying neoplastic cells in cases of nodular Lymphocyte-Predominant Hodgkin’s Disease. In contrast, anti-bcl-6 rarely stains Mantle-Cell Lymphoma and MALT Lymphoma. bcl-6 antibody expression is seen in approximately 45% of CD30+ Anaplastic Large-Cell Lymphomas but is consistently absent in other peripheral T-cell Lymphomas.

Antibody TypeRabbit MonoclonalCloneEP278
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlTonsil, Lymph Node, Thymus, Skin, Breast, Brain, Follicular Lymphoma
Presentationbcl-6 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2817PredilutedReady-To-Use3.0 ml
BSB 2818PredilutedReady-To-Use7.0 ml
BSB 2819PredilutedReady-To-Use15.0 ml
BSB 2820Concentrated1:25-1:1000.1 ml
BSB 2821Concentrated1:25-1:1000.5 ml
BSB 2822Concentrated1:25-1:1001.0 ml
BSB 2823Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: Bcl 6, Bcl6, anti-bcl6, anti-bcl-6, anti-bcl 6, sc7388, sc-7388, 7388, anti-Bcl-6, anti Bcl-6, anti-Bcl 6, anti-Bcl6, anti Bcl 6, anti Bcl6, BCL6 transcription repressor, anti-BCL6 transcription repressor, anti BCL6 transcription repressor, B cell CLL lymphoma 6, B cell lymphoma 6 protein, B cell lymphoma 6 protein transcript, BCL 5, BCL5, BCL6A, cys his2 zinc finger transcription factor, LAZ3, lymphoma associated zinc finger gene on chromosome 3, ZBTB27, Zinc finger and BTB domain containing protein 27, zinc finger protein 51, zinc finger transcription factor BCL6S, ZNF51, B cell lymphoma 5 protein, Protein LAZ 3