bcl-6 Antibody Immunohistochemistry on an FFPE Tonsil Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation|
bcl-6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein. Antibodies to this protein stain the germinal center cells in lymphoid follicles, follicular cells and interfollicular cells in Follicular Lymphoma, Diffuse Large B-Cell Lymphomas, Burkitt’s Lymphoma, and the majority of the Reed-Sternberg cells in Nodular Lymphocyte-Predominant Hodgkin’s Disease.
The bcl-6 antibody is also useful in identifying neoplastic cells in cases of nodular Lymphocyte-Predominant Hodgkin’s Disease. In contrast, anti-bcl-6 rarely stains Mantle-Cell Lymphoma and MALT Lymphoma. bcl-6 antibody expression is seen in approximately 45% of CD30+ Anaplastic Large-Cell Lymphomas but is consistently absent in other peripheral T-cell Lymphomas.
|Antibody Type||Rabbit Monoclonal||Clone||EP278|
|Localization||Nuclear||Control||Tonsil, Lymph Node, Thymus, Skin, Breast, Brain, Follicular Lymphoma|
|Presentation||bcl-6 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|