ace2 ace-2 anti-ace2 anti-ace-2 antibody immunohistochemistry ihc

ACE2 Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

Angiotensin Converting Enzyme 2 is a dipeptidyl carboxydipeptidase active in the renin-angiotensin pathway, which helps regulate cardiovascular and renal functions. ACE2 is a secreted protein that cleaves angiotensin I (AngI) into angiotensin 1-9, and angiotensin II (AngII) into vasodilator angiotensin 1-7. ACE2 is expressed in the heart and kidney, where it may counteract vasoconstriction by inactivating Ang II. It is also found in the GI tract, lungs, and testis, in endothelial cells and less in vascular smooth muscle cells. ACE2 can contribute to tumor inhibition by inactivating AngII, which has been found to participate in tumor proliferation, angiogenesis, and metastasis. 

ACE2 has shown inhibitory effects on lung, prostate, breast, and liver cancer through various signaling mechanisms, and its expression may be correlated with immune cell penetration into the tissue. ACE2 also functions as the main receptor for the spike glycoprotein of human coronaviruses HCoV-NL63, SARS-CoV and SARS-CoV-2.

Antibody Type Mouse Monoclonal Clone BSB-135
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Membranous, Cytoplasmic Control Kidney, Testis, Brain, Colon, Fallopian Tube
Presentation ACE2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB-3702-3 Prediluted Ready-To-Use 3.0 ml
BSB-3702-7 Prediluted Ready-To-Use 7.0 ml
BSB-3702-15 Prediluted Ready-To-Use 15.0 ml
BSB-3702-01 Concentrated 1:25-1:100 0.1 ml
BSB-3702-05 Concentrated 1:25-1:100 0.5 ml
BSB-3702-1 Concentrated 1:25-1:100 1.0 ml
BSB-3702-CS Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: ace2, ace-2, anti-ace2, anti-ace-2, sars-cov-2 receptors, sars cov-2 receptors, covid-19 receptors, sars-cov-2 antibodies sars-cov-2 ihc, sars-cov-2 immunohistochemistry
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