ace2 ace-2 anti-ace2 anti-ace-2 antibody immunohistochemistry ihc

ACE2 Antibody Immunohistochemistry on a FFPE SARS-CoV-2 Infected Lung Tissue

Specification Sheets
Safety Data Sheet
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Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Angiotensin Converting Enzyme 2 is a dipeptidyl carboxydipeptidase active in the renin-angiotensin pathway, which helps regulate cardiovascular and renal functions. ACE2 is a secreted protein that cleaves angiotensin I (AngI) into angiotensin 1-9, and angiotensin II (AngII) into vasodilator angiotensin 1-7. ACE2 is expressed in the heart and kidney, where it may counteract vasoconstriction by inactivating Ang II. It is also found in the GI tract, lungs, and testis, in endothelial cells and less in vascular smooth muscle cells. ACE2 can contribute to tumor inhibition by inactivating AngII, which has been found to participate in tumor proliferation, angiogenesis, and metastasis. 

ACE2 has shown inhibitory effects on lung, prostate, breast, and liver cancer through various signaling mechanisms, and its expression may be correlated with immune cell penetration into the tissue. ACE2 also functions as the main receptor for the spike glycoprotein of human coronaviruses HCoV-NL63, SARS-CoV and SARS-CoV-2.

Antibody TypeMouse MonoclonalCloneBSB-135
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationMembranous, CytoplasmicControlKidney, Testis, Brain, Colon, Fallopian Tube
PresentationACE2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB-3702-3PredilutedReady-To-Use3.0 ml
BSB-3702-7PredilutedReady-To-Use7.0 ml
BSB-3702-15PredilutedReady-To-Use15.0 ml
BSB-3702-01Concentrated1:25-1:1000.1 ml
BSB-3702-05Concentrated1:25-1:1000.5 ml
BSB-3702-1Concentrated1:25-1:1001.0 ml
BSB-3702-CSControl Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Synonyms: ace2, ace-2, anti-ace2, anti-ace-2, sars-cov-2 receptors, sars cov-2 receptors, covid-19 receptors, sars-cov-2 antibodies sars-cov-2 ihc, sars-cov-2 immunohistochemistry