IHC of A-1 Antichymotrypsin on an FFPE Tonsil Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||
Alpha-1-Antichymotrypsin Glycoprotein found in alpha (1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.
Alpha-1-Antichymotrypsin antibody reacts with histiocytes and histiocytic neoplasms. Its major application is defining the presence of Alpha-1-Antichymotrypsin in histiocytes and tumors derived from them. In eosinophilic granuloma and malignant histiocytosis, the reaction for this marker is heterogeneous in intensity and distribution. In fibrous histiocytomas, under certain circumstances, a diffuse homogeneous reaction may be observed.
|Antibody Type||Rabbit Monoclonal||Clone||EP384|
|Localization||Cytoplasmic||Control||Tonsil, Lymph Node, Thymus, Breast|
A-1-Antichymotrypsin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Special Note: Concentrated A-1-Antichymotrypsin antibody should be diluted to its working dilution in ImmunoDNA Background Blocker (Cat.# BSB 0103, BSB 0104, BSB 0105, BSB 0106 or BSB 0107).
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|