Bio SB performs R&D, production, distribution and marketing of unique products for Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescent in situ hybridization (FISH), Chromogenic in situ hybridization (CISH), Liquid-Based Cytology (LBC) and Polymerase Chain Reaction (PCR) technologies that meet the highest international standards for applications in Molecular Pathology, Cancer Research, Microbiology, Immunology and Genetics. BIO SB manufactures and develops products in accordance with FDA QSR 21 CFR Part 820 cGMP.
Synaptophysin is a synaptic vesicle glycoprotein weighing 38 kDa. It is present in endocrine cells, the brain, spinal cord, and adrenal glands. It acts as a marker for neuroendocrine cells. Synaptophysin reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas and gastrointestinal mucosa. Positive staining is seen in neurons of the brain, spinal cord, retina, and Paneth’s cells in the gastrointestinal tract and gastric parietal cells. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely-granular cytoplasmic staining is observed and probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of Synaptophysin is independent of the presence of NSE or other neuroendocrine markers. Synaptophysin is an independent broad-range marker of neural and neuroendocrine differentiation.
Synaptophysin is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.