Synaptophysin IVD Antibody

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Intended Use For In Vitro Diagnostic Use
Summary and Explanation Synaptophysin is a synaptic vesicle glycoprotein weighing 38 kDa. It is present in endocrine cells, the brain, spinal cord, and adrenal glands. It acts as a marker for neuroendocrine cells. Synaptophysin reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas and gastrointestinal mucosa. Positive staining is seen in neurons of the brain, spinal cord, retina, and Paneth’s cells in the gastrointestinal tract and gastric parietal cells. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely-granular cytoplasmic staining is observed and probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of Synaptophysin is independent of the presence of NSE or other neuroendocrine markers. Synaptophysin is an independent broad-range marker of neural and neuroendocrine differentiation.
Antibody Type Rabbit Polyclonal Clone N/A
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Pancreas
Presentation Synaptophysin is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5945 Prediluted Ready-To-Use 3.0 ml
BSB 5946 Prediluted Ready-To-Use 7.0 ml
BSB 5947 Prediluted Ready-To-Use 15.0 ml
BSB 5948 Concentrated 1:250-1:1000 0.1 ml
BSB 5949 Concentrated 1:250-1:1000 0.5 ml
BSB 5950 Concentrated 1:250-1:1000 1.0 ml
BSB 5951 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.