Vimentin
 |
| IHC of WT1 on a FFPE Kidney Tissue |
Product Description
Vimentin is a member of the intermediate filament family of proteins. Intermediate filaments are an important structural feature of eukaryotic cells. They, along with microtubules and actin microfilaments, make up the cytoskeleton.
Expression of vimentin, when used in conjunction with keratin, is helpful when distinguishing melanomas from undifferentiated carcinomas and large cell lymphomas. All melanomas and Schwannomas react strongly with vimentin. This antibody recognizes a 57 kDa intermediate filament. It labels a variety of mesenchymal cells, including melanocytes, lymph cells, endothelial cells, and firbroblasts. Non-reactivity of vimentin antibody is often considered more useful than its presence, since there are a few tumors that do not contain vimentin, e. g. hepatoma and seminoma.
Antibody Type: Mouse Monoclonal.
Clone: V9.
Isotype: IgG1/K.
Localization: Cytoplasmic.
Control: Tonsil, Lymph Node .
| Catalog # |
Presentation |
Volume
|
| BSB 6023 |
prediluted |
7 ml |
| BSB 6024 |
prediluted |
15 ml |
| BSB 6025 |
concentrated |
0.1 ml |
| BSB 6026 |
concentrated |
0.5 ml |
| BSB 6027 |
concentrated |
1 ml |
| BSB 6028 |
Vimentin, 5 + control slides |
|
|
WT1
 |
| IHC of ZAP-70 on a FFPE Tonsil Tissue |
Product Description
Wilms’ Tumor Protein (WT1) is a suppressor gene located on chromosome 11p13. Mutations of the WT1 gene on chromosome 11 are observed in approximately 20% of Wilms tumors. At least half of the Wilms tumors with mutations in WT1 also carry mutations in CTNNB1, the gene encoding the proto-oncogene beta-catenin.
Wilms' tumor is a neoplasm of the kidneys that typically occurs in children. It is also known as a nephroblastoma. WT1 has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian cystadenocarcinoma, gonadoblastoma, nephroblastoma and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody.
Antibody Type: mouse Monoclonal.
Clone: 6F-H2.
Isotype: IgG1, kappa.
Localization: Nuclear.
Control: Malignant Mesothelioma, Kidney and Testicle .
| Catalog # |
Presentation |
Volume
|
| BSB 6030 |
prediluted |
7 ml |
| BSB 6031 |
prediluted |
15 ml |
| BSB 6032 |
concentrated |
0.1 ml |
| BSB 6033 |
concentrated |
0.5 ml |
| BSB 6034 |
concentrated |
1 ml |
| BSB 6035 |
WT1, 5 + control slides |
|
|
ZAP-70
Product Description
ZAP-70 is an abbrevation for Zeta-chain-associated protein kinase 70 (70 is the molecularweight in kDa). The protein is a member in the protein-tyrosine kinase family. ZAP-70 isnormally expressed in T cells and natural killer cells and has a critical role in the initiation of T-cell signaling.
ZAP-70 in B cells is used as a prognostic marker in identifying different forms of chronic lymphocytic leukemia (CLL). ZAP-70 protein is expressed in leukemic cells of approximately 25% of Chronic Lymphocytic Leukemia (CLL) cases as well. ZAP-70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (ZAP-70 negative) and Ig-unmutated (ZAP-70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The ZAP-70 positive Ig-unmutated CLL cases have a poorer prognosis.
Antibody Type: Mouse Monoclonal.
Clone: 2F3.2.
Isotype: IgG2a.
Localization: Cytoplasmic.
Control: Tonsil, Lymph Node, Chronic Lymphocytic Leukemia .
| Catalog # |
Presentation |
Volume
|
| BSB 6037 |
prediluted |
7 ml |
| BSB 6038 |
prediluted |
15 ml |
| BSB 6039 |
concentrated |
0.1 ml |
| BSB 6040 |
concentrated |
0.5 ml |
| BSB 6041 |
concentrated |
1 ml |
| BSB 6042 |
Zap-70, 5 + control slides |
|
|
|
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