Bio SB performs R&D, production, distribution and marketing of unique products for Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescent in situ hybridization (FISH), Chromogenic in situ hybridization (CISH), Liquid-Based Cytology (LBC) and Polymerase Chain Reaction (PCR) technologies that meet the highest international standards for applications in Molecular Pathology, Cancer Research, Microbiology, Immunology and Genetics. BIO SB manufactures and develops products in accordance with FDA QSR 21 CFR Part 820 cGMP.
Mammaglobin is a gene that encodes a 10 kDa glycoprotein. In humans, expression of the gene is limited to the adult mammary gland. A correlation between increased expression of the gene and Breast Cancer has been reported. Mammaglobin mRNA is present in high levels in human Breast Cancer cell lines and primary Breast Cancers. High levels of mRNA have been detected in normal human sweat glands as well, but are absent in Sweat Gland Tumors. Anti-Mammaglobin (31A5) has been shown to be effective in detecting up to 85% of Breast Carcinomas using immunohistochemical techniques. Studies investigating the detection of mRNA by RT PCR from circulating carcinoma cells in the peripheral blood of Breast Cancer patients have shown that mammaglobin is a highly-specific marker and correlates with several prognostic factors, such as lymph node involvement.
Anti-Mammaglobin (31A5) is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.