Mammaglobin IVD Antibody

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Intended Use For In Vitro Diagnostic Use
Summary and Explanation Mammaglobin is a gene that encodes a 10 kDa glycoprotein. In humans, expression of the gene is limited to the adult mammary gland. A correlation between increased expression of the gene and Breast Cancer has been reported. Mammaglobin mRNA is present in high levels in human Breast Cancer cell lines and primary Breast Cancers. High levels of mRNA have been detected in normal human sweat glands as well, but are absent in Sweat Gland Tumors. Anti-Mammaglobin (31A5) has been shown to be effective in detecting up to 85% of Breast Carcinomas using immunohistochemical techniques. Studies investigating the detection of mRNA by RT PCR from circulating carcinoma cells in the peripheral blood of Breast Cancer patients have shown that mammaglobin is a highly-specific marker and correlates with several prognostic factors, such as lymph node involvement.
Antibody Type Rabbit Monoclonal Clone EP249
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Breast Carcinoma
Presentation Anti-Mammaglobin (31A5) is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5743 Prediluted Ready-To-Use 3.0 ml
BSB 5744 Prediluted Ready-To-Use 7.0 ml
BSB 5745 Prediluted Ready-To-Use 15.0 ml
BSB 5746 Concentrated 1:25-1:100 0.1 ml
BSB 5747 Concentrated 1:25-1:100 0.5 ml
BSB 5748 Concentrated 1:25-1:100 1.0 ml
BSB 5749 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.