CA15-3

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Intended Use For In Vitro Diagnostic Use
Summary and Explanation This antibody has been used for evaluating the primary site of a metastatic carcinoma of unknown origin and distinguishing between benign and malignant lesions. It is believed that CA15-3 reacts primarily with the DF3-antigen, a 300 kDa mucin-like glycoprotein present on the apical border of secretory mammary epithelial cells. CA15-3 has been detected with immunohistochemistry in a wide spectrum of carcinomas, including Breast Carcinomas (ductal and lobular), Sarcomas (Synovial Sarcoma and Malignant Fibrous Histiocytomas), and Lung Carcinomas. CA15-3 can be used as a supplementary marker for epithelial differentiation. CA15-3 does not stain Melanomas or Ewing’s Sarcomas. Approximately 30% of Hepatocellular Carcinomas are positive for CA15-3.
Antibody Type Mouse Monoclonal Clone DF3
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Breast, Pancreas, Salivary Gland
Presentation CA15-3 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5099 Prediluted Ready-To-Use 3.0 ml
BSB 5100 Prediluted Ready-To-Use 7.0 ml
BSB 5101 Prediluted Ready-To-Use 15.0 ml
BSB 5102 Concentrated 1:50-1:300 0.1 ml
BSB 5103 Concentrated 1:50-1:300 0.5 ml
BSB 5104 Concentrated 1:50-1:300 1.0 ml
BSB 5105 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.