IHC of WT1 on a FFPE Testicular Cancer Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||Wilms’ Tumor Protein (WT1) is a suppressor gene located on Chromosome 11p13. Mutations of the WT1 gene on Chromosome 11 are observed in approximately 20% of Wilms tumors. At least half of the Wilms tumors with mutations in WT1 also carry mutations in CTNNB1, the gene encoding the proto-oncogene beta-catenin.
Wilms’ tumor is a neoplasm of the kidneys that typically occurs in children. It is also known as a Nephroblastoma. WT1 has been identified in proliferative mesothelial cells, Malignant Mesothelioma, Ovarian Cystadenocarcinoma,
Gonadoblastoma, Nephroblastoma and Desmoplastic Small Round Cell Tumor. Lung Adenocarcinomas rarely stain positive with this antibody.
|Antibody Type||Mouse Monoclonal||Clone||6F-H2|
|Localization||Nuclear||Control||Testicle, Fallopian Tube, Kidney, Malignant Mesothelioma|
|Presentation||WT1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|