IHC of Uroplakin III on an FFPE Bladder TCC Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentation products of urothelial cells. In non-neoplastic mammalian urothelium, UPs are expressed in the luminal surface plasmalemma of superficial (umbrella) cells, forming complexes of 16-nm crystalline particles. Uroplakin III is expressed in urothelial carcinomas, whereas many non urothelial carcinomas were UPIII-negative. Recent studies have shown that UP expression might reflect the malignant potential of urothelial cancer cells as well as being cytodifferential markers of urothelial cells.
UPIII expression is strongly associated with lower tumor grades and lack of UPIII expression in urothelial tumors of the upper urinary tract is associated with much higher rates of metastases. Five-year specific survival is much worse for UPIII negative tumors (54%) than for UPIII positive tumors (100%). Apparently UPIII expression is a better indicator fo the malignant potential of the tumor than the grade of the tumor.
Antibody Type Rabbit Polyclonal Clone Polyclonal
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Bladder, Bladder Carcinoma
Presentation Uroplakin III antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2286 Prediluted Ready-To-Use 3.0 ml
BSB 2287 Prediluted Ready-To-Use 7.0 ml
BSB 2288 Prediluted Ready-To-Use 15.0 ml
BSB 2289 Concentrated 1:25-1:100 0.1 ml
BSB 2290 Concentrated 1:25-1:100 0.5 ml
BSB 2291 Concentrated 1:25-1:100 1.0 ml
BSB 2292 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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