Mart-1 & Tyrosinase

IHC of Tyrosinase on an FFPE Malignant Melanoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Tyrosinase is an enzyme that catalyzes the oxidation of phenols (such as tyrosine) and is widespread in plants and animals. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation. The gene for Tyrosinase is regulated by the Microphthalmia-associated transcription factor. A mutation in the tyrosinase gene leads to impaired tyrosinase production resulting in Type I Oculocutaneous Albinism, a hereditary disease that affects 1 in 17,000 people in the U.S.Anti-Tyrosinase has been found to be quite specific for melanotic lesions such as Malignant Melanoma and Melanotic Neurofibroma. Essentially no carcinomas express this marker.
Antibody Type Mouse Monoclonal Clone BSB-6
Isotype IgG2a Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Skin, Malignant Melanoma
Presentation Anti-Tyrosinase is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6008 Prediluted Ready-To-Use 3.0 ml
BSB 6009 Prediluted Ready-To-Use 7.0 ml
BSB 6010 Prediluted Ready-To-Use 15.0 ml
BSB 6011 Concentrated 1:50-1:200 0.1 ml
BSB 6012 Concentrated 1:50-1:200 0.5 ml
BSB 6013 Concentrated 1:50-1:200 1.0 ml
BSB 6014 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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