IHC of TRAcP on an FFPE Hairy Cell Leukemia Tissue

IHC of TRAcP on an FFPE Hairy Cell Leukemia Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Tartrate-resistant acid phosphatase (TRAcP) is a glycosylated monomeric metallo-enzyme expressed in mammals. It has a molecular weight of approximately 35 kDa, a basic isoelectric point (7.6 – 9.5), and optimal activity in acidic conditions. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. There are also certain pathological conditions whereby expression of TRAcP is increased. These include patients with Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher’s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases.Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts, which also express abundant TRAcP activity.
Antibody Type Mouse Monoclonal Clone 9C5
Isotype IgG2b Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Tonsil, Spleen, Lymph Node, Hairy Cell Leukemia
Presentation Anti-TRAcP is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5980 Prediluted Ready-To-Use 3.0 ml
BSB 5981 Prediluted Ready-To-Use 7.0 ml
BSB 5982 Prediluted Ready-To-Use 15.0 ml
BSB 5983 Concentrated 1:100-1:500 0.1 ml
BSB 5984 Concentrated 1:100-1:500 0.5 ml
BSB 5985 Concentrated 1:100-1:500 1.0 ml
BSB 5986 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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