IHC of TIA-1 on an FFPE Tonsil Tissue

IHC of TIA-1 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation TIA-1 (T-cell intracytoplasmic antigen) is a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15 kDa protein thought to be derived from the carboxyl terminus of the 40 kDa product by proteolytic processing. The expression of TIA-1 has been studied in Anaplastic Large Cell Lymphomas (ALCL), NK-cell Lymphomas, Peripheral T-cell Lymphomas, T-cell Lymphocytosis, B-cell Lymphomas and Lymphoblastic Leukemia, Hodgkin’s, etc. Studies show that 60 to 70% of Anaplastic Large Cell Lymphomas react with TIA-1. TIA-1 reacts with most Large Granular Lymphocytic Leukemias, Hepatosplenic T-cell Lymphomas, intestinal T-cell Lymphomas, NK-like T-cell Lymphomas, NK-cell Lymphomas, nasal T/NK-cell Lymphomas, subcutaneous T-cell Lymphomas and Pulmonary Angiocentric Lymphomas of T- or NK-phenotype. All B-cell Lymphomas, Hodgkin’s and Lymphoblastic Leukemias are negative for TIA-1.
Antibody Type Mouse Monoclonal Clone TIA-1
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Cytoplasmic (Granular) Control Tonsil, Spleen, Anaplastic Large Cell Lymphoma
Presentation TIA-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6352 Prediluted Ready-To-Use 3.0 ml
BSB 6353 Prediluted Ready-To-Use 7.0 ml
BSB 6354 Prediluted Ready-To-Use 15.0 ml
BSB 6355 Concentrated 1:25-1:100 0.1 ml
BSB 6356 Concentrated 1:25-1:100< 0.5 ml
BSB 6357 Concentrated 1:25-1:100< 1.0 ml
BSB 6358 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Related Products