IHC of TdT on anFFPE Acute Lymphoblastic Lymphoma Tissue

IHC of TdT on an FFPE Lymphoblastic Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Terminal Deoxynucleotidyl Transferase (also known as TdT and terminal transferase) is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells and acute Lymphoblastic Leukemia/ Lymphoma cells. TdT catalyzes the addition of nucleotides to the 3’ terminus of a DNA molecule. Unlike most DNA polymerases, it does not require a template. The preferred substrate of this enzyme is a protruding 3’ overhang, but it can also add nucleotides to blunt or recessed 3’ ends. TdT is normally found in cortical thymocytes and primitive lymphocytes. TdT antibody detects its antigen found in the nucleus of normal hematopoietic cells, normal cortical thymocytes and in the cytoplasm of megakaryocytes of the bone marrow. TdT expression is seen in over 90% of Acute Lymphocytic Leukemia cases with the exception of pre-B-Cell ALL, and normal mature T- or B-lymphocytes. TdT is positive for approximately one third of all cases of Chronic Myeloid Leukemia, making it a good indicator of better response to chemotherapy.
Antibody Type Rabbit Polyclonal Clone N/A
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control TdT Positive Lymphoma, Thymus
Presentation Anti-TdT is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5966 Prediluted Ready-To-Use 3.0 ml
BSB 5967 Prediluted Ready-To-Use 7.0 ml
BSB 5968 Prediluted Ready-To-Use 15.0 ml
BSB 5969 Concentrated 1:250-1:1000 0.1 ml
BSB 5970 Concentrated 1:250-1:1000 0.5 ml
BSB 5971 Concentrated 1:250-1:1000 1.0 ml
BSB 5972 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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