IHC of TCL1 on an FFPE Lymphoma Tissue

IHC of TCL1 on an FFPE Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is involved in T-cell prolymphocytic leukemia (T-PLL) and is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T-cell leukemia and B-cell lymphoma. TCL1 is expressed in more differentiated B-cells, under both reactive and neoplastic conditions, from antigen committed B-cells and in germinal center B-cells. TCL1 is down-regulated in the latest stage of B-cell differentiation.
TCL1 is overexpressed in Burkitt Lymphoma, the majority of AIDS-related non-Hodgkin’s Lymphoma-designated Immunoblastic Plasmacytoid Lymphoma, Lymphoblastic Lymphoma, Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B-cell Lymphoma, and Primary Cutaneous B-cell Lymphoma. Therefore, the most useful application of anti- TCL1 is the discrimination of B-cell lymphomas from T-cell lymphomas, CD30+ Anaplastic Large Cell Lymphomas, Multiple Myeloma, and Marginal Zone B-cell Lymphoma.
Antibody Type Rabbit Monoclonal Clone EP105
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear, Cytoplasmic Control Tonsil, Lymph Node
Presentation TCL1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2251 Prediluted Ready-To-Use 3.0 ml
BSB 2252 Prediluted Ready-To-Use 7.0 ml
BSB 2253 Prediluted Ready-To-Use 15.0 ml
BSB 2254 Concentrated 1:100-1:500 0.1 ml
BSB 2255 Concentrated 1:100-1:500 0.5 ml
BSB 2256 Concentrated 1:100-1:500 1.0 ml
BSB 2257 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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