T-bet

IHC of T-bet on an FFPE Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation T-bet, a T-box transcription factor, is expressed in CD4+ T-lymphocytes committed to T-helper (Th)1 T-cell development from naïve T-helper precursor cells (Thp) and redirects Th2 T cells to Th1 development.
T-bet is expressed in a significant subset of B-cell lymphoproliferative disorders, particularly at an early stage of B-cell development (precursor B-cell lymphoblastic leukemia/lymphoblastic lymphoma), and B-cell neoplasms derived from mature B cells, including CLL/SLL, marginal zone lymphoma, and hairy cell leukemia. In contrast, B-cell neoplasms derived from pregerminal center or germinal center B-cells, including mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma are negative for T-bet. Therefore, anti-T-bet should serve as a useful marker for the diagnosis and subtyping of B-cell and T-cell lymphoproliferative disorders.
Antibody Type Rabbit Monoclonal Clone EP263
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Spleen, Tonsil, Cervix, Lymphoblastic lymphoma, Hairy Cel leukemia, Bladder TCC
Presentation T-bet is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2601 Prediluted Ready-To-Use 3.0 ml
BSB 2602 Prediluted Ready-To-Use 7.0 ml
BSB 2603 Prediluted Ready-To-Use 15.0 ml
BSB 2604 Concentrated 1:25-1:100 0.1 ml
BSB 2605 Concentrated 1:25-1:100 0.5 ml
BSB 2606 Concentrated 1:25-1:100 1.0 ml
BSB 2607 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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