IHC of Survivin on an FFPE Colon Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. The survivin protein is expressed highly in most human tumors and fetal tissue, but is completely absent in terminally differentiated cells. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis.
The association of survivin expression with tumor progression, but not overall patient survival, has been observed in a variety of malignancies including renal cell carcinoma, ovary carcinoma, hepatocellular carcinoma, prostate carcinoma and breast carcinoma.
|Antibody Type||Rabbit Monoclonal||Clone||EP119|
|Localization||Nuclear||Control||Colon, Placenta, Testis, Tonsil, Bone Marrow, Colon Carcinoma, Lymphoblastic Lymphoma, Bladder TCC|
|Presentation||Survivin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|