IHC of SOX-2 on an FFPE Brain Tissue

IHC of SOX-2 on an FFPE Brain Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. It is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach.
SOX2 is expressed in fetal brain and is used as a marker for multipotential neural stem cells. In tumors, SOX2 expression is observed in teratoma of the central nervous system, melanoma, testicular germ cell tumor, cervical carcinoma, lung cancer, breast cancer with basal cell phenotype, and squamous cell carcinoma of the gastrointestinal tract. SOX2 may be useful in the identification of embryonal carcinoma. In stage I lung adenocarcinomas, SOX2 seems to be an independent predictor of poor outcome and may help stratify patients at increased risk for recurrence.
Antibody Type Rabbit Monoclonal Clone EP103
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Squamous Cell Carcinoma, Brain, Oligodendroglioma
Presentation SOX-2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2202 Prediluted Ready-To-Use 3.0 ml
BSB 2203 Prediluted Ready-To-Use 7.0 ml
BSB 2204 Prediluted Ready-To-Use 15.0 ml
BSB 2205 Concentrated 1:50-1:200 0.1 ml
BSB 2206 Concentrated 1:50-1:200 0.5 ml
BSB 2207 Concentrated 1:50-1:200 1.0 ml
BSB 2208 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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