IHC of SOX-11 on an FFPE Mantle Cell Lymphoma Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||Transcription factor SOX-11 is a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis. SOX-11 is normally expressed in the developing human central nervous system, Medulloblastoma, and Glioma.
Anti-SOX-11 nuclear protein expression is highly associated with both Cyclin D1-positive and negative Mantle Cell Lymphomas, with a stronger and more homogeneous Immunohistochemistry staining than Cyclin D1.
|Antibody Type||Mouse Monoclonal||Clone||CL0142|
|Localization||Nuclear||Control||Mantle Cell Lymphoma|
|Presentation||SOX-11 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|