IHC of S100A9 on an FFPE Melanoma Tissue

IHC of S100A9 on an FFPE Melanoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation S100A9, also known as migration inhibitory factor-related protein 14 (MRP-14) or calgranulin- B is a member of the S100 family of proteins containing 2 EF hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/ or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentation. S100A9 forms a heterodimer, Calprotectin, with S100A8 in a calcium-dependent manner. S100A9 may function in the inhibition of casein kinase.
S100A9 is expressed in granulocytes, monocytes in peripheral blood and in infiltrating macrophages in inflammatory sites, but not in normal tissue macrophages. Elevated plasma levels of S100A9 has been observed in inflammatory disorders such as chronic bronchitis, cystic fibrosis and rheumatoid arthritis. S100A9 is also detected in tumor cells in carcinomas of the liver, lung, breast and thyroid. It is correlated with tumor differentiation.
Antibody Type Rabbit Monoclonal Clone EP185
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Nuclear Control Tonsil, Liver, Lung, Breast, Cervix, Bone Marrow, Bladder TCC, Thyroid Carcinomas
Presentation S100A9 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2168 Prediluted Ready-To-Use 3.0 ml
BSB 2169 Prediluted Ready-To-Use 7.0 ml
BSB 2170 Prediluted Ready-To-Use 15.0 ml
BSB 2171 Concentrated 1:10-1:50 0.1 ml
BSB 2172 Concentrated 1:10-1:50 0.5 ml
BSB 2173 Concentrated 1:10-1:50 1.0 ml
BSB 2174 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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