IHC of S100A9 on an FFPE Melanoma Tissue

IHC of S100A9 on an FFPE Melanoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationS100A9, also known as migration inhibitory factor-related protein 14 (MRP-14) or calgranulin- B is a member of the S100 family of proteins containing 2 EF hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/ or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentation. S100A9 forms a heterodimer, Calprotectin, with S100A8 in a calcium-dependent manner. S100A9 may function in the inhibition of casein kinase.
S100A9 is expressed in granulocytes, monocytes in peripheral blood and in infiltrating macrophages in inflammatory sites, but not in normal tissue macrophages. Elevated plasma levels of S100A9 has been observed in inflammatory disorders such as chronic bronchitis, cystic fibrosis and rheumatoid arthritis. S100A9 is also detected in tumor cells in carcinomas of the liver, lung, breast and thyroid. It is correlated with tumor differentiation.
Antibody TypeRabbit MonoclonalCloneEP185
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic, NuclearControlTonsil, Liver, Lung, Breast, Cervix, Bone Marrow, Bladder TCC, Thyroid Carcinomas
PresentationS100A9 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2168PredilutedReady-To-Use3.0 ml
BSB 2169PredilutedReady-To-Use7.0 ml
BSB 2170PredilutedReady-To-Use15.0 ml
BSB 2171Concentrated1:10-1:500.1 ml
BSB 2172Concentrated1:10-1:500.5 ml
BSB 2173Concentrated1:10-1:501.0 ml
BSB 2174Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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