IHC of S100A8/MRP8 on an FFPE Colon Tissue

IHC of S100A8/MRP8 on an FFPE Colon Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Myeloid Related Protein 8 (MRP8), also known as S100A8, is a calcium binding protein that belongs to the S100 family. By a Ca2+ dependent manner, S100A8/A9 forms Calprotectin, a heterodimeric inflammatory mediator of inflammation found in the cytoplasm of neutrophils and expressed on the membrane of monocytes. S100A8 is expressed during myeloid differentiation and chronic inflammations, and it is expressed constitutively or induced in epithelial cells during dermatose.
S100A8 is expressed in cells with myeloid origin, including granulocytes, monocytes and macrophages, and it is observed in blood granulocytes and monocytes. It is also expressed in infiltrate macrophages during inflammatory reactions, but not in normal tissue macrophages. S100A8 also reacts with activated microglial cells in human cerebral malaria. In tumors, positive staining of S100A8 has been observed in various cancers including pancreatic cancer, and it has been linked to inflammation-associated cancers.
Antibody Type Rabbit Monoclonal Clone EP90
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Nuclear Control Tonsil, Breast, Liver, Fallopian Tube, Lymphoblastic Lymphoma
Presentation S100A8/MPR8 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2356 Prediluted Ready-To-Use 3.0 ml
BSB 2357 Prediluted Ready-To-Use 7.0 ml
BSB 2358 Prediluted Ready-To-Use 15.0 ml
BSB 2359 Concentrated 1:10-1:50 0.1 ml
BSB 2360 Concentrated 1:10-1:50 0.5 ml
BSB 2361 Concentrated 1:10-1:50 1.0 ml
BSB 2362 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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