IHC of PU.1 on an FFPE Lymphoma Tissue

IHC of PU.1 on an FFPE Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation PU.1 is a member of the Ets family of transcription factors and is required for the development of multiple hematopoietic lineages. It plays a pivotal role in normal myeloid differentiation and regulates the expression of immunoglobulin and other genes that are important for B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B lymphocytes, with the exception of plasma cells.
PU.1 is expressed in germinal center B-cells and mantle B-cells. The antibody is positive in various lymphomas including B-Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Marginal Zone Lymphoma, Burkitt Lymphoma, Diffuse Large Cell Lymphoma, Diffuse Large B-cell Lymphoma, T-cell rich B-cell Lymphoma, Nodular Lymphocyte Predominant Hodgkin Lymphoma. It has been demonstrated that a high level of expression of GC antigens (including PU.1) has a positive association with longer overall survival and progression free survival in the case of Follicular Lymphoma.
Antibody Type Rabbit Monoclonal Clone EP18
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Tonsil, Lymph Node
Presentation PU.1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2154 Prediluted Ready-To-Use 3.0 ml
BSB 2155 Prediluted Ready-To-Use 7.0 ml
BSB 2156 Prediluted Ready-To-Use 15.0 ml
BSB 2157 Concentrated 1:50-1:200 0.1 ml
BSB 2158 Concentrated 1:50-1:200 0.5 ml
BSB 2159 Concentrated 1:50-1:200 1.0 ml
BSB 2160 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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