IHC of PTEN on an FFPE Prostate Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation Phosphatase and tensin homolog (PTEN) is a protein that, in humans, is encoded by the PTEN gene. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating Akt/PKB signaling pathway.PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. During tumor development, mutations and deletions of PTEN occur that inactivate its enzymatic activity leading to increased cell proliferation and reduced cell death. Frequent genetic inactivation of PTEN occurs in glioblastoma, endometrial cancer, and prostate cancer; and reduced expression is found in many other tumor types such as lung and breast cancer. In breast and prostate cancer, loss of PTEN expression has been shown to correlate positively with advanced stage. Furthermore, PTEN mutation also causes a variety of inherited predispositions to cancer.
Antibody Type Rabbitt Monoclonal Clone RBT-PTEN
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Nuclear Control Colon, Thymus, Skin, Kidney, Breast, Prostate, Breast Carcinoma, Prostatic Carcinoma
Presentation PTEN is a rabbit monoclonal antibody derived from cell culture supernatant that
is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing
BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2643 Prediluted Ready-To-Use 3.0 ml
BSB 2644 Prediluted Ready-To-Use 7.0 ml
BSB 2645 Prediluted Ready-To-Use 15.0 ml
BSB 2646 Concentrated 1:25-1:100 0.1 ml
BSB 2647 Concentrated 1:25-1:100 0.5 ml
BSB 2648 Concentrated 1:25-1:100 1.0 ml
BSB 2649 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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