IHC of PMS2 on an FFPE Colon Carcinoma Tissue

IHC of PMS2 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation PMS2 is a gene that encodes for DNA repair proteins involved in mismatch repair. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells.
Along with MLH1, MSH2 and MSH6, PMS2 is helpful in diagnosing MSI. Tumors with low-level MSI show unfavorable pathological characteristics compared to tumors with none and tumors with high-level MSI.
Antibody Type Rabbit Monoclonal Clone EP51
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Colon Mucosa, Colon Carcinoma
Presentation PMS2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2119 Prediluted Ready-To-Use 3.0 ml
BSB 2120 Prediluted Ready-To-Use 7.0 ml
BSB 2121 Prediluted Ready-To-Use 15.0 ml
BSB 2122 Concentrated 1:25-1:100 0.1 ml
BSB 2123 Concentrated 1:25-1:100 0.5 ml
BSB 2124 Concentrated 1:25-1:100 1.0 ml
BSB 2125 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Related Products