IHC of PDGFR-B on an FFPE Breast Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Beta-type Platelet-Derived Growth Factor Receptor is a protein that in humans is encoded by the PDGFRB gene. This gene encodes a cell surface tyrosine kinase receptor for members of the Platelet-Derived Growth Factor family (PDGF), which is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB.
Translocation of the PDGFR gene with the Tel gene is linked to Chronic Myelomonocytic Leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Antibody Type Rabbit Monoclonal Clone RBT-PDGFRB
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control

Brain, Testis, Breast, Colon, Fallopian Tube

Presentation PDGFR-B is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2349 Prediluted Ready-To-Use 3.0 ml
BSB 2350 Prediluted Ready-To-Use 7.0 ml
BSB 2351 Prediluted Ready-To-Use 15.0 ml
BSB 2352 Concentrated 1:10-1:50 0.1 ml
BSB 2353 Concentrated 1:10-1:50 0.5 ml
BSB 2354 Concentrated 1:10-1:50 1.0 ml
BSB 2355 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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