IHC of PAX-8 on an FFPE Ovarian Carcinoma Tissue

IHC of PAX-8 on an FFPE Ovarian Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. Studies have also found PAX-8 experession in renal tubules as well as renal carcinoma, nephroblastoma and seminoma. Normal lung and lung carcinomas do not express PAX-8. Similarly, the absence of expression of PAX-8 in breast and other non-GYN carcinomas other than those primary to the thyroid indicates that PAX-8 is an important new marker of ovarian cancer and a useful marker for the differential diagnoses in lung and neck tumors, or tumors at distant sites where primary lung carcinoma or thyroid carcinoma are possibilities.
PAX-8, combined with organ system-specific markers such as uroplakin, mammaglobin, and TTF-1 can be a very useful panel to determine the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast.
Antibody Type Rabbit Monoclonal Clone ZR-1
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Ovary, Thyroid
Presentation PAX-8 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2098 Prediluted Ready-To-Use 3.0 ml
BSB 2099 Prediluted Ready-To-Use 7.0 ml
BSB 2100 Prediluted Ready-To-Use 15.0 ml
BSB 2101 Concentrated 1:25-1:100 0.1 ml
BSB 2102 Concentrated 1:25-1:100 0.5 ml
BSB 2103 Concentrated 1:25-1:100 1.0 ml
BSB 2104 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Related Products