IHC of p53 on an FFPE Breast Carcinoma Tissue

IHC of p53 on an FFPE Breast Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation p53 (also known as tumor protein 53 [TP53]) is a transcription factor that regulates the cell cycle and, hence, functions as a tumor suppressor. p53 has been described as ”the guardian of the genome”, referring to its role in conserving stability by preventing genome mutation. p53 has many anti-cancer mechanisms. It can activate DNA repair proteins when DNA has sustained damage; it can also hold the cell cycle at the G1/S regulation point on DNA damage recognition. It can initiate apoptosis, programmed cell death, if DNA damage proves to be irreparable. p53 is central to many of the cell’s anti-cancer mechanisms. It can induce growth arrest, apoptosis and cell senescence. Mutations involving p53 have been found in a wide variety of malignant tumors, including Breast, Ovarian, Bladder, Colon, Lung, and Melanoma.
Antibody Type Mouse Monoclonal Clone DO7
Isotype IgG2b/K Reactivity Paraffin, Frozen
Localization Nuclear Control Lung, Breast, Ovarian, Prostate, Colon Carcinoma
Presentation p53 clone DO7 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5841 Prediluted Ready-To-Use 3.0 ml
BSB 5842 Prediluted Ready-To-Use 7.0 ml
BSB 5843 Prediluted Ready-To-Use 15.0 ml
BSB 5844 Concentrated 1:250-1:1000 0.1 ml
BSB 5845 Concentrated 1:250-1:1000 0.5 ml
BSB 5846 Concentrated 1:250-1:1000 1.0 ml
BSB 5847 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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