IHC of p27 on an FFPE Breast Adenocarcinoma Tissue

IHC of p27 on an FFPE Breast Adenocarcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation p27KIP1 is a cell cycle regulatory mitotic inhibitor of Cdk activity. p27KIP1 is a candidate-tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 is up-regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Low p27 expression has been associated with unfavorable prognosis in Renal-cell Carcinoma,Colon Carcinoma, Small Breast Carcinomas, Non-small-cell Lung Carcinoma, Hepatocellular Carcinoma, Multiple Myeloma, lymph node metastases in Papillary Carcinoma of the Thyroid, and a more aggressive phenotype of Carcinoma in the Cervix.
Antibody Type Mouse Monoclonal Clone SX53G8
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Nuclear Control Prostate, Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma
Presentation Anti-p27 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5834 Prediluted Ready-To-Use 3.0 ml
BSB 5835 Prediluted Ready-To-Use 7.0 ml
BSB 5836 Prediluted Ready-To-Use 15.0 ml
BSB 5837 Concentrated 1:25-1:100 0.1 ml
BSB 5838 Concentrated 1:25-1:100 0.5 ml
BSB 5839 Concentrated 1:25-1:100 1.0 ml
BSB 5840 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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