IHC of p120 Catenin on an FFPE Breast Carcinoma Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||p120 Catenin is a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Cytoplasmic accumulation of p120 Catenin has been observed in lung cancer, pancreatic cancer, gastric cancer and colon cancers and is associated with poor prognosis in colon cancer patients.
In breast lobular neoplasia, anti-p120 Catenin shows a diffuse cytoplasmic immunostaining pattern, while breast ductal neoplasia retains the membrane immunostaining pattern. p120 Catenin can be useful in differentiating between lobular carcinoma and ductal carcinoma of the breast, and in identifying early lesions of lobular neoplasia.
|Antibody Type||Rabbit Monoclonal||Clone||EP66|
|Localization||Membranous, Cytoplasmic||Control||Breast, Testis, Kidney, Prostate, Pancreas, Tonsil, Salivary Gland, Skin, Cervix, Colon, Malignant Melanoma, Transitional Cell Carcinoma, Breast Lobular Carcinoma|
|Presentation||p120 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|