IHC of Napsin A on a FFPE Lung Carcinoma Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||
The activation peptides of aspartic proteinases play a role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional glycosylated aspartic proteinase precursor containg an RGD motif and an addition 18 residues at its C-terminus.
In normal tissue, anti-Napsin A labels type II pneumocytes in adult lung and epithelial cells in kidney tissues. In abnormal tissues, Napsin A is a useful marker for lung adenocarcinoma.
|Antibody Type||Mouse Monoclonal||Clone||BSB-112|
|Localization||Cytoplasmic||Control||Kidney, Lung, Renal Cell Carcinoma, Lung Carcinoma|
|Presentation||Napsin A is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|