IHC of MUC-4 on an FFPE Colon Tissue

IHC of MUC-4 on an FFPE Colon Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.        
 
Summary and Explanation Mucin 4 (MUC4) is a mucin protein that in humans is encoded by the MUC4 gene. Like other mucins, MUC4 is a high-molecular weight glycoprotein. MUC4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930 kDa for the actual protein. MUC4 antibody labels normal epithelial cells in the trachea, GI tract and prostate, but not in the pancreas.MUC-4 has been found to play various roles in the progression of cancer, particularly due to its signaling and anti-adhesive properties which contribute to tumor development and metastasis. It is also found to play roles in other diseases such as endometriosis and inflammatory bowel disease. An abnormal expression of MUC4 has been reported in various carcinomas of the colon, pancreas, breast, and ovaries. Increased expression of MUC4 has been observed in pancreatic carcinoma and cervical squamous carcinoma. MUC4 is helpful in differentiating lung adenocarcinoma (positive) from malignant mesothelioma (negative). Additionally, MUC4 is useful in the identification of low-grade fibromyxoid sarcoma (LGFMS), and sclerosing epithelioid fibrosarcoma. MUC4 expression is also detected in the glandular component of biphasic synovial sarcomas.
  Antibody Type Rabbitt Monoclonal Clone EP256
  Isotype IgG Reactivity Paraffin, Frozen
  Localization Cytoplasmic Control
Prostate, Liver, Kidney, Bladder TCC, Pancreatic Carcinoma and Cervical Squamous Carcinoma
 
Presentation MUC4 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
 
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2552 Prediluted Ready-To-Use 3.0 ml
BSB 2553 Prediluted Ready-To-Use 7.0 ml
BSB 2554 Prediluted Ready-To-Use 15.0 ml
BSB 2555 Concentrated 1:25-1:100 0.1 ml
BSB 2556 Concentrated 1:25-1:100 0.5 ml
BSB 2557 Concentrated 1:25-1:100 1.0 ml
BSB 2555 Control Slides   5
  Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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