IHC of MSH6 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation MSH6, also known as mutS homolog 6, is a gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset Colorectal Carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited Colorectal Cancer in the western world. MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H).
The anti-MSH6 antibody is useful in screening patients and families for HNPCC. Colon cancers that are microsatellite-unstable have a better prognosis than their microsatellite-stable counterparts.
Antibody Type Rabbit Monoclonal Clone EP49
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Colon Mucosa, Colon Carcinoma
Presentation MSH6 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6932 Prediluted Ready-To-Use 3.0 ml
BSB 6933 Prediluted Ready-To-Use 7.0 ml
BSB 6934 Prediluted Ready-To-Use 15.0 ml
BSB 6935 Concentrated 1:50-1:200 0.1 ml
BSB 6936 Concentrated 1:50-1:200 0.5 ml
BSB 6937 Concentrated 1:50-1:200 1.0 ml
BSB 6938 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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